There were age-related trends in the genotypic distributions of those who became alcohol dependent in any of the four age ranges in the illicit drug subsample. For the first trend test, of the change of genotypic distribution with age of those who became alcohol dependent at any age, the hypothesis of no trend could be rejected at a 0.003 level for rs978437, rs7800170, and rs1824024, SNPs which were significant for alcohol dependence in the entire population, and at a 0.035 level for rs2061174 and rs2350786. This means that in those who became alcohol dependent, having two copies of the major allele was the prevalent condition for who became alcohol dependent in the earliest age range, while not having two copies of the major allele was the prevalent condition of those who become alcohol dependent in the oldest age range.
