For the second trend test, of the change of genotypic distribution with time from initiation of alcohol use to time of alcohol dependence of those who began regular alcohol use in the youngest age range and who became alcohol dependent at any age, the hypothesis of no trend could be rejected at a 0.025 level for all of the SNPs. This means that in those who became immediately alcohol dependent, having two copies of the major allele was the prevalent condition, while in those who took the longest to become alcohol dependent, not having two copies of the major allele was the prevalent condition. The results are presented in table 4. This suggests a genetic influence on the rapidity of the transition from regular alcohol use to alcohol dependence among those who become regular alcohol users in the earliest age range.
