In LD, none of the alcohol response measures (peak BrAC change scores at high dose or low dose) predicted trajectory group, binge, or any drinking outcome during the follow-up. For HD at the high dose, greater ratings of like(r=+0.37; P<.001) and want more (r=+0.38; P < .001) and lower ratings of sedation(r=−0.20;P<.05)were significantly linearly associated with subsequent drinking trajectory group, indicating an overall moderate effect (Figure 5). Ratings at the low alcohol dose for like(r=+0.24;P<.05) and want more (r=+0.23; P<.05) were also predictive of drinking trajectory group, but the association was weaker than for the high dose. Cortisol response for either high or low dose did not predict drinking behavior.