Analyses using the generalized estimation equations approach confirmed that in HD, greater alcohol stimulation, greater liking, greater wanting, and lower sedation at the high dose predicted greater binge drinking frequency during follow-up (P < .001 for all). Greater liking and wanting responses to the low dose of alcohol also related to future binge drinking, but again these were not as strong as those observed with the high dose. Composite generalized estimation equations models that included all the significant alcohol responses indicated that greater alcohol stimulation (P<.05), greater liking (P<.001), and lower sedation (P<.05)for high dose remained significant predictors of future drinking. These analyses were repeated for alcohol responses during the ascending (30-minute) and descending (120-minute) BrAC limbs. On the ascending limb, alcohol wanting (P<.001)was a significant predictor of future drinking, and on the descending limb, liking (P<.001), wanting (P<.01), and less sedation (P<.01) predicted future drinking. Although disinhibited personality and FH predicted future drinking in HD, controlling for these factors did not alter the relationships between alcohol responses and subsequent drinking behavior. For HD, increases in liking(odds ratio[OR]{SE},29.81{29.42};P=.001) and want
