less sedation (P<.01) predicted future drinking. Although disinhibited personality and FH predicted future drinking in HD, controlling for these factors did not alter the relationships between alcohol responses and subsequent drinking behavior. For HD, increases in liking(odds ratio[OR]{SE},29.81{29.42};P=.001) and want more (OR [SE],7.43 [5.32]; P=.005) were significantly associated with alcohol use disorder diagnosis during follow-up. When binge drinking pattern was included in the model, the magnitude of association for alcohol response to alcohol use disorder was reduced (like: OR [SE], 14.64 [15.04]; P<.01; and want more: OR [SE],3.51 [2.64]; P=.10), suggesting that binge drinking partially (like) or fully (want more)mediated the relationship between alcohol response and subsequent alcohol use disorder.
