We also computed four ratio scores of FH density (FHDr). Briefly, the density measures accounted for the degree of relatedness of different categories of biological relatives, weighted based on their AUD affectedness. The mathematical formulations used for calculating these density measures are elaborated in the supplementary material. Specifically, the density measures accounted for 1) Two variations in the weighting scheme and inclusion of family members. That is, the set of relatives included were either (a) primary and secondary non-descendants (e.g., parents, grandparents, parental siblings, full siblings, and half-siblings) (FHDrPSND) or (b) all relatives, regardless of degree or direction of relatedness, including both predecessors and descendants (FHDrAR). 2) Two variations in affectedness coding criteria. That is, for coding family members’ AUD affectedness, the two criteria were (a) DSM-5 AUD lifetime diagnosis (AUDDx) and (b) DSM-5 AUD maximum symptom count (AUDMaxSxCnt). For DSM-5 maximum symptom count, the maximum number of endorsed symptoms at any one assessment across multiple assessments was used. This variable was transformed by the natural logarithm of the symptom count plus one (i.e., ln (count + 1)). Accordingly, for
