Of 1,251,157 imputed SNPs, 1,079,979 (86%) had MAF>0.01 and INFO>0.8. The quantile–quantile plots of the observed versus expected −log(P) from the four (total, male, female and REO) association analyses are presented in Figure 1 and Supplementary File 1. The genomic control λ (the median χ2 association statistic divided by the median expected under the null) shows no evidence for inflation of the test statistics. For example, for the full analysis, λ=1.05 (and standardized to a sample size of 1000, λ1000=1.02). There were no genome-wide significant results with P<5 × 10−8. The Manhattan plot of association P-values for all subjects is presented in the Supplementary File 1 and Table 3 shows associations with <1 × 10−5 in any analysis. Regional association and forest plots are provided in Supplementary File 2. SNPs associated with P<0.001 in any analysis are provided in Supplementary File 3.
