Chunk #13 — Materials and methods — Gene-based tests

Source

Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.

Embedded

yes

Text

To determine whether any genes harbored an excess of SNPs with small P-values, we undertook genome-wide gene-based tests which account for both gene length and linkage disequilibrium between SNPs using VEGAS.30 SNPs were allocated to one or more autosomal genes using gene boundaries ±50 kb. We investigated 183 candidate genes for MDD.12, 13, 14, 15, 31