Meta-analysis showed that a total of 523 SNPs were nominally associated with alcohol dependence (3.1×10−8≤p≤0.049), including 3 SNPs that survived genome-wide Bonferroni correction (p=3.1×10−8 for rs4478858, p=3.8×10−8 for rs2275436 and p=4.7×10−8 for rs1039630; α=5×10−8), 34 SNPs with p<10−6, 158 SNPs with p<10−5, 244 SNPs with p<10−4, and 183 SNPs that survived region-wide and cohort-wide correction (α=1.7×10−5). Furthermore, all 92 replicable SNPs were nominally associated with alcohol dependence in meta-analysis (3.1×10−8≤p≤0.020), including the aforementioned 3 SNPs that survived genome-wide Bonferroni correction (α=5×10−8), 7 SNPs with p<10−6, 69 SNPs with p<10−5, 83 SNPs with p<10−4, and 77 SNPs that survived region-wide and cohort-wide correction (α=1.7×10−5).
