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Chunk #34 — Methods — UK Biobank sample

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Item-level analyses reveal genetic heterogeneity in neuroticism.
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yes

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For both samples specified above, we used newly imputed data from the 2nd release, on ~96 million genetic variants. Imputation was performed by the UK Biobank, using a reference panel that included the UK10K haplotype panel as well as the Haplotype Reference Consortium reference panel. Based on recommendations by the UKB we excluded all variants imputed from the UK10K reference panel, as technical errors may have occurred during the imputation process. The imputed data was converted to hard-called genotypes using a certainty threshold of 0.9.