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Chunk #35 — Methods — Neuroticism phenotype

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Item-level analyses reveal genetic heterogeneity in neuroticism.
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Neuroticism was measured using the Eysenck Personality Questionnaire, Revised Short Form (EPQ-R-S)11, consisting of 12 dichotomous items (‘yes’ or ‘no’). Participants completing <9 items were excluded from further analysis. We constructed a weighted neuroticism sum-score by adding up the individual item responses and dividing this sum by the total number of completed items (see Supplementary Tables 1, 2 and 5 for the endorsement rates of the individual items in both samples, as well as in the full sample). Prior to analysis, the sum-score was standardized to have mean 0 and variance 1.