ASB is known to correlate with an array of phenotypes [20-22]. At the same time there has been a growing availability of publicly accessible genetic data across these phenotypes. To test whether these phenotypic associations are also reflected in genetic correlations we performed analyses with LDSC in a selection of 73 traits and diagnoses (Supplementary Table 15 and Fig. 3). We found strong correlations between ASB and reproductive traits (e.g., younger age of first birth (rg = −0.58, s.e. = 0.06, p = 2.93 × 10−15)), cognitive traits (e.g., fewer years of schooling (rg = −0.49, s.e. = 0.06, p = 1.94 × 10−10)), anthropometric traits (e.g., increased waist-to-hip ratio (rg = 0.32, s.e. = 0.05, p = 5.59 × 10−6)), neuropsychiatric traits (e.g., more depressive symptoms (rg = 0.63, s.e. = 0.07, p = 2.45 × 10−16)) and smoking related traits (e.g., ever smoked (rg = 0.54, s.e. = 0.08, p = 1.48 × 10−7)). It is important to emphasize here that correlation, even when genetic, does not imply causation.
