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Chunk #15 — RESULTS — Heritability and polygenic scoring — Polygenic risk scoring in five independent cohorts. — Quebec Newborn Twin Study (QNTS):

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Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis.
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In Canada, participants were derived from the QNTS study (N = 341). We tested two phenotypes and found a significant association for one. We computed a factor score based upon five teacher-rated assessments of ASB in youngsters during primary school (age range = 6–12 years). We found that higher PRS were associated with a higher factor score of ASB (p = 0.001, for p value thresholds 0.4, adjusted delta R2 = 3.9%, Supplementary Table 14). We failed to find evidence for an association between PRS and self-reported ASB in young adults (p > 0.05).