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Chunk #6 — Methods — Measures — Alcohol use disorder (AUD)

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Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples.
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We used SSAGA interviews to construct lifetime criteria counts of DSM-5 AUD25 in each sample. Because individuals in COGA are potentially interviewed multiple times, we used the highest criteria count ever reported by each subject. In FT12, lifetime criteria counts were measured at the young adult interview. In addition to criteria counts, we created AUD thresholds for those who met criteria for mild (2+ criteria), moderate (4+ criteria), or severe (6+ criteria) AUD25 without clustering. In both FT12 and COGA, individuals who had never initiated alcohol use were coded as missing.