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Chunk #7 — Methods — Measures — Other substance use disorders (SUD)

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Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples.
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We constructed lifetime criteria counts of cannabis, cocaine, and opioid use disorders based on DSM-5 criteria. We measured nicotine dependence criteria using the Fagerstrom Test for Nicotine Dependence (FTND), which assesses six criteria and has values ranging from 0 to 10 in both COGA and FT12. Because many illicit SUDs were not measured or rare in the FT12 data, we limit analyses of illicit SUD to COGA. Like AUD, these criteria counts represent the maximum reported for each respondent across the course of the study. Criteria counts for each substance were limited to those who indicated ever using the corresponding substance. In the case of FTND, this is limited to those who report smoking 100+ cigarettes in their lifetime.