AD PRS (p-threshold < 0.001) was associated with increased EEG coherence in COGA participants (low theta, high theta, low alpha, high alpha). Only associations in low theta and high alpha frequency bands with PRS threshold p < 0.001 in males met the initial selection criterion, with the majority of coherence pairs in these frequency bands showing strong association with AD PRS in ages 18–31 (effect sizes ranged from 0.15 to 0.21 with all p-values < 10−4, see Table 2 and Supplemental Figure S2). The most robust associations were observed in fronto-central (FZ-CZ–F3-C3), temporo-parietal (T8-P8–T7-P7), centro-parietal (C4-P4–C3-P3, C3-P3–CZ-PZ), and parieto-occipital (P4-O2–P3-O1) coherences; p-values ranged from 5 × 10−5 through 5 × 10−8 (Figure 2, top panel). A false discovery rate estimation for correlated data with a criterion of 10−3 was applied to the entirety of the results for low theta and high alpha (2592 values per band). For low theta, associations with p-values< 3.2 × 10−4 met this criterion and for high alpha associations with p-values < 3.9 × 10−4 met this criterion (Table 2). Additionally, robust associations were also observed
