A history of any mental disorder strongly predicted the development of substance dependence. For instance, nicotine, alcohol, cannabis or cocaine users diagnosed with a mood disorder or a PD were more likely to become dependent on those substances than individuals who did not report having had any of these disorders. As presented in table 4, controlling for the effect of other covariates did not appreciably modified the results. Nicotine, alcohol or cannabis users diagnosed with an anxiety disorder showed an increased risk of becoming dependent on these substances in the adjusted models. A lifetime diagnosis of a psychotic disorder increased the risk of developing nicotine dependence among nicotine users in the adjusted model.
