Having a history of SUD predicted a further development of an additional SUD (Table 4). Individuals diagnosed with nicotine dependence were more likely to develop alcohol dependence among alcohol users, and cannabis dependence among cannabis users. Nicotine, cannabis and cocaine users diagnosed with alcohol dependence showed a higher risk of developing dependence on these substances. Nicotine, alcohol and cocaine users diagnosed with cannabis dependence showed increased hazards of developing dependence on these substances. Nicotine, alcohol and cannabis users diagnosed with cocaine dependence were more likely to develop dependence on these substances.
