To look for converging evidence from genetic and genomic studies, we compiled a list of genes whose expression is altered in humans, genes implicated by genome wide association studies (GWAS), and genes whose expression was altered in previous studies of alcohol preferring and non-preferring rats (P and NP, including both naïve states and P animals exposed to alcohol). Many genes in the present study overlapped with the previously implicated genes (Figure 2); specific genes are marked in Supplementary Table 1, which has references for all 29 studies used. Since we were interested in how the present data could inform human studies, we examined which pathways were significantly overrepresented from the 713 genes found in the intersection between this study and the human studies, using IPA. 36 pathways were altered (FDR ≤ 0.10, Supplementary Table 5). These include signaling pathways related to serotonin, cAMP, CREB, oxidative stress, dopamine, Crh and axonal guidance. Fos and Jun, which were included in many of the altered pathways, have also been frequently identified in other experiments using P animals and alcohol (Supplementary Table 1). Among
