paperKB
coga / coga-kb
Help
Sign in

Chunk #27 — 3. Results — 3.3 Converging evidence

Source
Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.
Embedded
yes

Text

to serotonin, cAMP, CREB, oxidative stress, dopamine, Crh and axonal guidance. Fos and Jun, which were included in many of the altered pathways, have also been frequently identified in other experiments using P animals and alcohol (Supplementary Table 1). Among the genes in the intersection, 564 were found in the human post-mortem studies even though most examined frontal cortex and none measured the DRN. Among these are several genes related to myelin, which have decreased expression in the DRN as they had in multiple post-mortem human studies (e.g. Mayfield et al., 2002; McClintick et al., 2013).