After correction for multiple testing, analyses that were seeded with the 235 top-ranked genes (p < 0.001) identified in the GWAS revealed nicotinic acetylcholine receptor activity (nAChR) as the only significant pathway (adjusted p = 3.6 × 10−2). Among the genes in this pathway, CHRNA3, CHRNB4, and CHRNA5 contained SNPs that were associated with stimulant dependence in the combined population (Table 4).Table 4Top-ranked associations of stimulant dependence with individual variants in each of three adjacent nicotinic acetylcholine receptor genes observed in the discovery GWAS in African American and European ancestry groups.PopulationGeneSNP IDChr: positionp-valueAfrican AmericanCHRNA3rs1696996815:788829255.6E−04CHRNA5rs203652715:788547066.6E−02CHRNB4rs19024567415:789132071.1E−02European AncestryCHRNA3rs1696996815:788829252.9E−06CHRNA5rs1290071115:788539981.2E−05CHRNB4rs1290751915:789133533.8E−06
