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Chunk #22 — Discussion

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Expanding the range of ZNF804A variants conferring risk of psychosis.
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Meta-analysis P-values for rs1344706[T], based on the results from this study and the original report, were 2.8×10−9 (OR= 1.10) for schizophrenia and 3.8×10−11 (OR= 1.11) for psychosis, making association with both of these phenotypes unequivocal. In addition, three schizophrenia GWA studies1,2,22 recently reported association results for rs1344706[T], although the samples used by each study at least partially overlap the material included here or in the original study. The International Schizophrenia Consortium (ISC) achieved a one-tailed P-value of 0.029 (OR= 1.08) based on 2519 cases and 2110 controls, of which about 650 cases and 650 controls were included in this study.1 The Molecular Genetics of Schizophrenia (MGS) consortium reported a two-tailed P-value of 0.026 (OR= 1.10) using about 5300 samples, of which ~1900 were part of the original ZNF804A study.2 A third GWA study gave results for a rs1344706 surrogate;22 however, the Aberdeen samples used in that study are entirely incorporated into this study. In addition, while this work was under review, a replication study using the Irish Case–Control Study of Schizophrenia (ICCSS) sample reported a one-tailed P-value of 0.011 (OR=