Chunk #27 — RESULTS — Repeated, but not Acute, Restraint Stress Prolongs DSI in BLA

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Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.

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4.4% N = 17 vs acute stress 86.3 ± 4.5% N = 13, p > 0.05; Figure 5b) or late DSI (control 99.9 ± 4.0% N = 17 vs acute stress 100.6 ± 4.6 N = 13, p < 0.05; Figure 5b) relative to control mice. These data indicate that exposure to repeated, but not acute, restraint stress confers an increased capacity for 2-AG-mediated synaptic signaling in the BLA.