and other substance use disorders implicated a more severe clinical course, that held for alcohol as well as other substances. 33 Other analyses investigated evidence in COGA of a previously established AUD subtype, Type A‐B clusters, 34 finding that among affected individuals in COGA, 5 items usefully distinguished the two types with positive clinical applications. 35 Altogether, data on in‐depth characterization of a broad range of alcohol and other substance misuse problems, as well as other psychopathology, obtained in the members of the COGA families, have supported numerous analyses in the presentation and familial aggregation of alcohol problems. In this area, COGA not only has provided evidence to support past findings by reproduction of results from prior studies, but also has contributed fresh insights into key issues in AUD nosology and familial transmission that have served as a catalyst for further investigations in other data sources by other researchers.
