Genetic risk scores (GRS) are constructed using the independent Airwave study74 data to assess the combined effect of the BP-associated variants on BP and risk of hypertension (Supplementary Note), whilst avoiding bias by “winners curse”. We create weighted GRSs for all pairwise-independent, LD-filtered (r2 < 0.2) previously reported variants at the time of analysis and our validated variants (sentinel and secondary SNVs) combined, using available SNVs (Supplementary Table 22). For the previously reported variants, we weight BP increasing alleles by the beta coefficients from the UKB analysis. For our validated variants, beta coefficients of the replication meta-analysis are used as independent, unbiased weights.
