Correlation clustering was performed to show that iPSCs were overall similar to hESCs rather than to differentiated cells, and NSC and dopaminergic neurons differentiated from them appeared more similar to each other. The overall correlation coefficient between each population was calculated by Pearson's rho (Table 1) and presented by a dendrogram analysis (Fig. 4A). This is consistent with our immunological and functional analysis, which suggests that iPSCs differentiate using similar cues and signals as hESCs, and that the overall process of differentiation and the end phenotype are similar to hESC-derived products.
