Subjects for this study were 686 relatives of probands, from 460 families, from the Collaborative Study on the Genetics of Alcoholism (COGA) who met criteria for DSM-5 alcohol use disorder (AUD; American Psychiatric Association, 2013) in the year preceding the baseline interview and who participated in a follow-up interview 5 years later. As described elsewhere (Bucholz et al., 1996; Culverhouse et al., 2005; Nurnberger et al., 2004; Reich, 1996), COGA is a multi-site, high-risk family study of alcohol dependence. Probands for COGA were recruited from treatment settings at 6 sites across the United States and were required to meet criteria for DSM-III-R-defined alcohol dependence (American Psychiatric Association, 1987) and Feighner definite alcoholism (Feighner et al., 1972). Probands were also required to have at least two first-degree relatives living in one of the COGA catchment areas available for study. All of these first-degree relatives were sought for baseline interviews and for follow-up interviews approximately 5 years later. The protocol was approved by the institutional review board at each site, and written informed consent was obtained from all subjects. Of the subjects
