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Chunk #13 — Results — Subjects

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Alcohol use disorder causes global changes in splicing in the human brain.
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Demographics and pertinent clinical data are listed in Table 1. Patients with AUD and control subjects did not differ in age, gender, ethnic origin, or BMI; nor were there differences in brain weight and brain volume between the two groups (P > 0.05). Likewise, RNA integrity numbers of RNA samples were similar between control and AUD groups (P > 0.05, Supplementary Fig. 1).Table 1Baseline characteristics of patients with alcohol use disorder (AUD) and control subjects.Control, n = 30AUD, n = 30DemographicsAge (SE)57.5 (1.6)57.5 (1.6)Gender, males, n (%)23 (77)23 (77)Ethnic origin, Europeans, n (%)26 (87)30 (100)Brain characteristicsWeight, g (SE)1433 (25)1381 (25)volume, cm3 (SE)1409 (24)1364 (24)SE standard error. Two-tailed Student’s t test was used to calculate the difference between patients with AUD and control subjects.