Analysis of expression of 57 820 total gene features (coding and noncoding) showed that AUD is associated with relatively moderate changes in brain transcriptome (with FDR cutoff <0.05). Thus, the most affected brain region was a basolateral amygdala (BLA), in which only 102 genes were differentially expressed. In the superior frontal cortex (SFC), nucleus accumbens (NA), and central nucleus of the amygdala (CNA), 23, 14, and 57 genes were altered, respectively (Fig. 1). The majority of affected genes (73.5%) were represented by protein-coding genes followed by long noncoding RNAs (20.9%) (Supplementary Fig. 2).
