Final data analysis was restricted to autosomal, bi-allelic SNPs with MAF > 0.0001, high imputation quality (INFO score ≥0.9) and low missingness (<0.05), resulting in 10,847,151 SNPs. Within each SNP-based GWA analysis, we applied the standard genome-wide significance threshold in European-descent samples40 of P < 5 × 10−8. In addition, we indicate whether the genetic signal survived correction for the 13 phenotypes tested (P < 3.85 × 10−9; Supplementary Data 2; Supplementary Fig. 4).
