The interaction effect of childhood or adolescent parental divorce/separation and parental history of alcohol problems on offspring lifetime DSM-IV alcohol dependence was assessed via an interaction term in a logistic regression model adjusted for demographics and parental history of drug, depression, and antisocial behavior problems. This interaction term was significant (F=−2.9, p = 0.003). Table 2 presents the prevalence of and odds ratios for offspring lifetime alcohol dependence for those without childhood or adolescent parental divorce/separation or parental history of alcohol problems, those with one or the other, and those with both. After adjusting for demographics and parental history of drug, depression, and antisocial behavior problems, those who endorsed childhood or adolescent parental divorce/separation and parental history of alcohol problems were more than two times as likely to report lifetime alcohol dependence than those from non-divorced/separated families where neither parent had alcohol problems (AOR = 2.37). Those who experienced parental alcohol problems but not childhood or adolescent parental divorce/separation were also more than two times as likely to report lifetime alcohol dependence compared to respondents with neither divorce/separation nor alcohol
