The additive effects of childhood or adolescent parental divorce/separation and parental history of alcohol problems on the odds of offspring lifetime alcohol dependence are shown in Table 1. After adjusting for demographics and parental history of drug, depression, and antisocial behavior problems, childhood or adolescent parental divorce/separation was a significant predictor of offspring lifetime alcohol dependence (Adjusted Odds Ratio [AOR] = 1.33), as was parental history of alcohol problems (AOR = 2.26).