Bioinformatics analysis shows that 4 SNPs are located in the transcription factor binding sites (TFBS), including rs4147541 at 5' regulatory region of ADH1C, rs4478858 at SERINC2 and rs1057239 and rs1894709 at KIAA0040. They may affect the local DNA conformation, and thereby influence the binding of TFBS (40). Two SNPs, rs2275436 at SERINC2 and rs6425323 at KIAA0040, are located within CpG islands, whose methylation status may affect the expression of the neighbor genes (41). All of the three significant SNPs at SERINC2 are located within CNVs. rs1229984 (Arg47Asn) at ADH1B is located in exonic splicing silencers (ESS) or enhancers (ESE). rs2066702 (Arg370Cys) at ADH1B is predicted to be with high confidence to affect ADH1B function or structure. Furthermore, 8 SNPs are predicted to significantly or highly significantly alter the RNA secondary structures, including rs28864441, rs2173201 and rs4147541 at ADH cluster, rs2275436 at SERINC2, rs750338 at PKNOX2, rs2842576 at NRD1, rs9825310 between GPD1L and CMTM8, and rs7916403 at HTR7. Eight SNPs are predicted to mildly alter the RNA secondary structures, including rs1789891 and rs4699748 at ADH cluster, rs4478858 at SERINC2, rs6701037 and
