There are many genes in which multiple SNPs in the 3’UTR affected expression. The very long 3’ UTR of KIF6 (kinesin family member 6) contained 13 SNPs that were tested, and of those, 7 showed significant allele-biased expression in both neuronal cell lines (FDR < 0.2), of which 2 (rs56370893 and rs16891940, both associated with the flushing phenotype) were significant at FDR < 0.05. GAS7 (growth arrest specific 7) had 4 significant SNPs; it is broadly expressed in brain, primarily in terminally differentiated cells, especially mature cerebellar Purkinje neurons, and plays a role in neuronal development. NBN (nibrin; also known as NBS1), with 2 significant SNPs, is involved in double-strand break repair. PKD1L2 (polycystin 1 like 2) has 4 functional SNPs. SIRPA (signal regulatory protein alpha; 2 SNPs) encodes a transmembrane glycoprotein that regulates receptor tyrosine kinase signaling. SIRPA is expressed ubiquitously in brain at high levels, primarily in neurons, macrophages and dendritic cells. ADD2 (adducin 2, expressed only in brain and hematopoietic tissues) had 3 significant SNPs. CRKL (CRK like proto-oncogene, adaptor protein) had 2 significant SNPs; it encodes
