Chunk #21 — Results — Genome-wide association analysis, biological annotation, gene, and transcriptome-based association analyses

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Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

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We identified two genome-wide significant loci: rs3791033 near the genes KDM4A and PTPRF (p = 3.80E−08), and rs640561 near LRRIQ3 (p = 3.80E−08; Fig. 1, Supplementary Table 3 and Supplementary Fig. 1 and 2 for locus zoom plots). Both loci are on chromosome 1, but rs3791033 and rs640561 are independent (r2 < 0.001).