Chunk #20 — Results — Genome-wide association analysis, biological annotation, gene, and transcriptome-based association analyses

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Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

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We examined 11,311,983 SNPs in all 132,113 study participants. The inflation factor of the GWAS was λGC = 1.097 with an LDSC intercept of 1.004 (SE = 0.008), suggesting that the majority of the inflation was due to polygenicity. The SNP heritability of POU on the liability scale was SNP-h2 = 0.04 ± 0.01.