Regarding comorbidity and related characteristics during the 5-year follow-up, group 4 members had significantly more often suicide attempts, suicidal ideation and, not surprisingly, a manic episode than groups 1 and 2 individuals. However, 3 individuals (of n = 30) with baseline bipolar II and comorbid alcohol dependence reported a manic episode during follow-up. Furthermore, subjects of group 4 attempted more often suicide compared to group 3 individuals.