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Chunk #17 — 3. RESULTS — 3.1. Associations between Nicotine Dependence and Comorbid Psychiatric Disorders

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Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes.
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Table 2 shows rates and odds ratios for comorbid disorders among cases and controls stratified by gender, adjusted for age and education. Nicotine dependence was associated with examined psychiatric disorders similarly across gender with few exceptions. In women, nicotine dependence was associated with an increased risk of social phobia (OR=2.16, 95% CI=1.58-2.97, p=1.7E-06), but not in men (OR=1.14, 95%CI=0.72-1.81, p=0.58), and the difference was significant (wald=4.90, p=0.027). The associations between nicotine dependence and other examined disorders were not statistically different across gender, so in the subsequent analyses the genders were analyzed together.