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Chunk #21 — Results — Subjective effects and cortisol response

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Acute alcohol response phenotype in heavy social drinkers is robust and reproducible.
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As shown in Table 2, the second cohort responded to alcohol in an identical pattern as the original cohort across all measures. In the second cohort, alcohol significantly increased reports of stimulation (p < 0.0001), liking (p < 0.0001), wanting more (p < 0.0001), and sedation (p < 0.0001) in a limb-specific fashion without affecting cortisol secretion. There were no differences between the cohorts on subjective measures (Table 2 and Figure 1a – c) or salivary cortisol response. These findings provide support for a full replication of all the results presented in King et al. (2011a).