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Chunk #12 — 3. Results — 3.1 Evaluation of diazepam and THC on marble burying

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Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.
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Similarly, the plant-derived cannabinoid THC reduced marble burying [F(7,64) = 31.1; p < 0.0001; Figure 1C], but caused profound hypomotility at doses greater than 3 mg/kg [F(7,1216) = 70.6; p < 0.0001; Figure 1D]. Post hoc analyses revealed that marble burying was decreased at 0.3, 10, and 30 mg/kg, but not at 1 or 3 mg/kg, THC.