Rs9291283 was nominally associated with adult AAD in the CADD and combined CADD and GADD samples. Although rs9291283 has been previously shown to be nominally associated with alcohol dependence (Covault et al. 2004; Soyka et al. 2008; Bierut et al. 2010), rs279858 has been the most well replicated SNP in GABRA2 associated with adult alcohol dependence (Edenberg et al. 2004; Covault et al. 2004; Lappalainen et al. 2005; Fehr et al. 2006; Bierut et al. 2010; Villafuerte et al. 2011; Li et al. 2013), a finding which failed to replicate in our study. This result may be related to slight differences in the alcohol phenotypes examined. Most of the previous studies (Edenberg et al. 2004; Covault et al. 2004; Lappalainen et al. 2005; Fehr et al. 2006; Drgon et al. 2006; Soyka et al. 2008; Covault et al. 2008; Enoch et al. 2009; Bierut et al. 2010; Olfson and Bierut 2012; Philibert et al. 2009; Ittiwut et al. 2012; Li et al. 2013) have focused specifically on alcohol dependence. However, recent item response theory work has shown that AAD symptoms
