Having argued that some IFs and IRRs should indeed be considered for return, we next address the specific responsibilities involved. Identifying the core responsibilities will allow us to consider who in the complex system of biobank research is best positioned to discharge them and how. Four key responsibilities are: Clarifying the criteria to determine what kind of findings are returnable, and the roster of returnable IFs and IRRs;Analyzing a particular finding to decide whether it should be offered to the individual contributor;Re-identifying that contributor (or contributors, if more than one is affected by the finding); andRecontacting the contributor(s) to offer the finding and genetic or other appropriate counseling.
