The GWAS meta-analysis for females only (N=8535, Table S2b) revealed three loci approaching genome-wide significance on chromosome 1 (rs2764450, p= 4.8 x 10-8, R2=.35%) and 11 (rs11215217, p= 2.1 x 10-8, R2=.37%), whereas the meta-analysis for males (N=7772, Table S2c) identified a near genome-wide signal on chromosome X (rs41456347, p= 2.0 x 10-8, R2=.41%). We found no evidence for heterogeneity (I2=0) across discovery samples in the association of rs2764450 (p=.45), rs11215217 (p=.54) and rs41456347 (p=.60) with ASB (see Figure S4 for forest plots). Functional annotation was carried out for the top three loci to gain insight into possible causal genes (see Chapter 7 and Figure S5). Top signals were located differently across sex, which is illustrated by the Miami plot in Figure 1 and Table S5. We tested whether the signs of the regression coefficients were consistently in the same direction between the SNPs for males and females. The sign tests showed no consistent directions of effect (proportion was .51, .50 and .50 respectively) for SNPs selected for different p-value thresholds (.05, .001 and .0001). Moreover, Fisher exact tests showed
