Our data provide the first functional evidence of the maturation‐dependent changes in membrane conductances that occur in human oligodendrocytes as they differentiate from OPCs. We demonstrate that during differentiation and maturation human oligodendroglia recapitulate many of the changes in ion channel expression observed in rodent‐based systems. Using this platform, we show that the multiple properties of mutant C9ORF72 ALS oligodendrocyte‐lineage cells, including membrane properties and maturation, are not impaired.
