studies should be conducted to evaluate the potential cross effect with other common substances such as marijuana. In spite of the multiple group differences observed, the results show few relationships with AUDIT and FTND, which could be indication of pre-existing brain states unrelated to drug use. It could also indicate that observed differences might be better captured by other covariates not considered in this study. Another possible explanation is the stationary behavior assumed for the time courses in the applied method. Methods that analyze dynamic connectivity, e.g. (Allen et al., 2012), can identify and separate brain states which may exhibit closer relationship with behavioral measures. Finally, this study was designed as a resting state analysis free of important cognitive measures that can be obtained using different task paradigms. Our observations are then limited to task-free outcomes and leave a cognitive evaluation for future work and experimentation.
