While this is the first multi-modal study that uses EEG-based source connectivity to examine alcohol-related memory problems, which is an important alcohol-related neurocognitive outcome, it has some limitations: (i) the sample size of the study groups is rather small and the findings are therefore only preliminary, (ii) while the groups are matched based on important variables, stratified analyses based on age, sex, and self-reported race and genetic ancestry, may identify more relevant features specific to each category; (iii) some of the variables were not considered for matching (e.g., memory status during baseline, relatedness among group members, comorbid diagnoses such as substance use, anti-social personality disorder, attention-deficit hyperactivity disorder, etc.), which may have impacted the results; (iv) the memory problems reported by the study sample can be heterogeneous and the assessment of alcohol-related memory problems was only based on oral self-reports and not a psychometric measure; studies that are currently underway are assessing this sample with comprehensive neurocognitive assessments, including memory function, and will be more objective and quantitative; (v) the study does not consider genomic or other trait-related baseline effects
