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Chunk #17 — Results — Pre-Test Comparisons

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Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity.
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As shown in Table 2, the two genotype groups did not differ on demographics or on measures of alcohol use and problems. There was a trend towards G-allele carriers being younger (p = .09) and reporting fewer drinking episodes in the past month (p = .06). In addition, A-allele homozygotes were more likely to be regular smokers (p< .05) and reported a higher total number of drinks over the past 30 days (p< .05), as compared to G-allele carriers. Based on the TLFB data collected immediately prior to each infusion session, the average time between infusion and last drink was 2.03 days (SD = 0.94). This interval did not differ by genotype group, t(41) = −0.26, p = .80. Likewise, the prevalence of the alcohol withdrawal symptom did not differ by genotype, χ2(1) = 0.72, p = .40, suggesting that alcohol withdrawal is an unlikely confound in these analyses.