As a manipulation check, a series of simple models tested the effects of Alcohol, Time, and the Alcohol × Time interaction on the dependent variables of interest. As expected, results revealed a significant Alcohol × Time interaction on craving (AUQ, β = 0.21, SE = 0.11, t = 2.04, p< .05) and positive mood (POMS, β = 0.15, SE = 0.06, t = 2.70, p< .01). There were also trend-level Alcohol × Time interaction effects on stimulation (BAES, β = 1.94, SE = 1.01, t = 1.87, p = .06) and vigor (POMS, β = 0.09, SE = 0.05, t = 1.62, p = .10). There was a main effect of alcohol on sedation (BAES, β = 5.10, SE = 1.72, t = 2.95, p< .01). Effects were in the hypothesized direction, in that alcohol predicted stronger subjective responsesthan saline across time. There was no significant effect of genotype or genotype × alcohol interaction at baseline on any of the dependent variables of interest (ps> .10). Likewise, there was no significant effect of alcohol (versus placebo) on baseline ratings of
