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Chunk #19 — Results — Pre-Test Comparisons

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Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity.
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across time. There was no significant effect of genotype or genotype × alcohol interaction at baseline on any of the dependent variables of interest (ps> .10). Likewise, there was no significant effect of alcohol (versus placebo) on baseline ratings of the BAES, POMS, and AUQ (ps> .10). In addition to the linear term, we also tested non-linear effects (quadratic parameters) for the progression of subjective responses across rising BrACs. Doing so resulted in quadratic parameters that were not significant (main effect or interactions with genotype or alcohol) and were therefore excluded from subsequent analyses, while the linear parameters were retained.