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Chunk #19 — Materials and Methods — Smoking-related diseases — Abdominal aortic aneurysm

Source
A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences.
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Iceland Icelanders with abdominal aortic aneurysms (AAAs) were recruited from a registry of individuals who were admitted either for emergency repair of symptomatic or ruptured AAA, or for an elective surgery to the Landspitali University Hospital, in Reykjavik, Iceland, in 1980–2011. Individuals (with an unruptured aneurysm⩾30 mm) were also recruited through a high-risk screening of first-degree relatives of AAA patients. To study early-onset AAA we considered subjects diagnosed with AAA before reaching age 65.